Ziac Dosage/Direction for Use

The usual starting dose is one tablet bisoprolol + hydrochlorothiazide (Ziac) 2.5 mg/6.25 mg once daily. If the antihypertensive effect of this dosage is inadequate, the dose will be increased to one tablet bisoprolol + hydrochlorothiazide (Ziac) 5 mg/6.25 mg once daily and, if response is still inadequate, to one tablet bisoprolol + hydrochlorothiazide (Ziac) 10 mg/6.25 mg once daily.
Duration of treatment: Treatment with bisoprolol + hydrochlorothiazide (Ziac) is generally a long-term therapy.
Gradual discontinuation of bisoprolol treatment is recommended, since abrupt withdrawal of bisoprolol may lead to an acute deterioration of the patient's condition, in particular in patients with ischemic heart disease.
Administration: Take bisoprolol + hydrochlorothiazide (Ziac) tablet in the morning, with or without food. Swallow the tablet with some liquid. Do not chew.
Special Populations: Patients with renal or hepatic impairment: No dose adjustment is necessary in patients with mild-to-moderate hepatic impairment or mild-to-moderate renal impairment (creatinine clearance > 30 mL/min).
Elderly: No dosage adjustment is normally required in the elderly.
Pediatric patients: Experience with bisoprolol + hydrochlorothiazide (Ziac) in pediatric patients is limited, therefore its use cannot be recommended in this population.