Zepim Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Cefepime HCl

Indications/Uses

Infections due to susceptible organisms eg, UTI, resp tract & skin infections.

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Dosage/Direction for Use

Administer IV over approx 30 min. Adult Moderate to severe pneumonia 1-2 g IV 12 hrly for 10 days. Empiric therapy for febrile neutropenic patient 2 g IV 8 hrly for 7 days or until resolution of neutropenia. Mild to moderate uncomplicated or complicated UTI including pyelonephritis 0.5-1 g IV/IM 12 hrly for 7-10 days. Severe uncomplicated or complicated UTI including pyelonephritis &/or moderate to severe uncomplicated skin & skin structure infections 2 g IV 12 hrly for 10 days. Complicated intra-abdominal infections (used in combination w/ metronidazole) 2 g IV 12 hrly for 7-10 days. Normal renal function CrCl >60 mL/min 500 mg 12 hrly, 1 g 12 hrly, 2 g 12 hrly, 2 g 8 hrly. Renal insufficiency CrCl 30-60 mL/min 500 mg 24 hrly, 1 g 24 hrly, 2 g 24 hrly, 2 g 12 hrly; 11-29 mL/min 500 mg 24 hrly, 500 mg 24 hrly, 1 g 24 hrly, 2 g 24 hrly. <11 mL/min 250 mg 24 hrly, 250 mg 24 hrly, 500 mg 24 hrly, 1 g 24 hrly. Continuous ambulatory peritoneal dialysis 500 mg 48 hrly, 1 g 48 hrly, 2 g 48 hrly, 2 g 48 hrly. Hemodialysis 1 g on day 1, then 500 mg 24 hrly, 1 g 24 hrly. Febrile neutropenia 1 g on day 1 then 1 g 24 hrly.

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Overdosage

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Contraindications

Hypersensitivity to cefepime or cephalosporins, penicillins or other β-lactam antibiotics.

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Special Precautions

Prolonged use may result in overgrowth of nonsusceptible microorganisms. Monitor prothrombin time. History of GI disease particularly colitis. Renal or hepatic impairment; +ve Coombs' test. Pregnancy & lactation. Childn <2 mth. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Encephalopathy including confusion, hallucinations, stupor & coma; myoclonus & seizures; pseudomembranous colitis.

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Drug Interactions

Increased potential of nephrotoxicity & ototoxicity w/ high doses of aminoglycosides. Nephrotoxicity may occur w/ potent diuretics eg, furosemide.

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Storage

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Description

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Action

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MIMS Class

Cephalosporins

ATC Classification

J01DE01 - cefepime ; Belongs to the class of fourth generation cephalosporins. Used in the systemic treatment of infections.

Regulatory Classification

Presentation/Packing

Form

Zepim powd for inj 1 g

Packing/Price

(vial) 1's (P1,995/vial)

Zepim

cefepime

Manufacturer:

Kyongbo

Distributor:

PHARMASIA