Zenith Suspension/Zenith OD Suspension Overdosage

Zenith Suspension: Adverse events experienced in higher than recommended doses were similar to those seen at normal doses.
Symptoms: The typical symptoms of an overdose with macrolide antibiotics include reversible loss of hearing, severe nausea, vomiting and diarrhoea.
Treatment: In the event of overdose, the administration of medicinal charcoal and general symptomatic treatment and supportive measures are indicated as required.
Zenith OD Suspension: Adverse events experienced in higher than recommended doses were similar in nature but may be more frequent than those seen at usual doses. Clinical features of an overdose with macrolides may include reversible hearing loss, severe nausea, vomiting and diarrhea. In case of an overdose, the administration of medicinal charcoal, general symptomatic measures are indicated as required.
Multiple doses of azithromycin, as with cationic amphiphilic drugs, have been shown to induce phospholipidosis (intracellular phospholipid accumulation) in some tissues of mice, rats and dogs. This has been demonstrated in dogs at doses 2 to 3 times greater than the recommended human dose, and in rats at doses comparable to human dose. The effect is reversible upon discontinuation of azithromycin treatment. The clinical significance of these findings in humans is not known.