Zanidip Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Lercanidipine HCl

Indications/Uses

Mild to moderate essential HTN.

Click to view Zanidip detailed prescribing information

Dosage/Direction for Use

Adult 10 mg once daily, may be increased to 20 mg.

Click to view Zanidip detailed prescribing information

Overdosage

View Zanidip overdosage for action to be taken in the event of an overdose.

Administration

Should be taken on an empty stomach: Take at least 15 min before meals.

Contraindications

Hypersensitivity. Left-ventricular outflow tract obstruction; untreated CHF; unstable angina pectoris or recent (w/in 1 mth) MI. Severe hepatic or renal (GFR <30 mL/min) impairment, including patients undergoing dialysis. Co-administration w/ strong CYP3A4 inhibitors, cyclosporin, grapefruit/grapefruit juice.

Click to view Zanidip detailed prescribing information

Special Precautions

Patients w/ sick sinus syndrome (w/o a pacemaker), left ventricular dysfunction, ischaemic heart disease. Development of cloudy peritoneal effluent in patients on peritoneal dialysis. Concomitant use w/ CYP3A4 inducers eg, anticonvulsants (eg, phenytoin, carbamazepine) & rifampicin; alcohol. Galactose intolerance, total lactase deficiency or glucose-galactose malabsorption. Minor influence on the ability to drive & use machines. Mild to moderate renal impairment. May enhance effect in patients w/ moderate hepatic impairment. Not recommended in women of childbearing potential not using contraception; during pregnancy & lactation. Childn <18 yr. Elderly.

Click to view Zanidip detailed prescribing information

Use In Pregnancy & Lactation

Click to view Zanidip detailed prescribing information

Adverse Reactions

Headache; tachycardia, palpitations; flushing; peripheral oedema.

Click to view Zanidip detailed prescribing information

Drug Interactions

Increased plasma levels w/ strong CYP3A4 inhibitors (eg, ketoconazole, itraconazole, ritonavir, erythromycin, troleandomycin, clarithromycin); cyclosporin. Inhibits metabolism w/ grapefruit or grapefruit juice. Reduced antihypertensive effect w/ CYP3A4 inducers eg, anticonvulsants (eg, phenytoin, phenobarb, carbamazepine) & rifampicin. Potentiated effect w/ alcohol. Increased absorption w/ midazolam. Reduced bioavailability w/ metoprolol. Mean increase in digoxin C_max. May increase bioavailability & hypotensive effect w/ higher dose of cimetidine. Increased hypotensive effects w/ other medications affecting BP eg, α-blockers, TCAs, neuroleptics. Reduced hypotensive effect w/ corticosteroids. Terfenadine, astemizole, class III anti-arrhythmics (eg, amiodarone, quinidine, sotalol).

Click to view Zanidip detailed prescribing information

Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Zanidip detailed prescribing information

Storage

View Zanidip storage conditions for details to ensure optimal shelf-life.

Description

View Zanidip description for details of the chemical structure and excipients (inactive components).

Action

View Zanidip mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Calcium Antagonists

ATC Classification

C08CA13 - lercanidipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.

Regulatory Classification

Presentation/Packing

Form

Zanidip FC tab 10 mg

Packing/Price

30's (P922.5/pack)

Form

Zanidip FC tab 20 mg

Packing/Price

28's (P1,251/pack)

Zanidip

lercanidipine

Manufacturer:

Abbott

Distributor:

Abbott