Xefu Special Precautions

Should be administered cautiously to the following patients: In principle, should not be administered to the patients with a history of hypersensitivity to this drug or cephalosporins. If necessary, should be given cautiously.
Patients with a history of hypersensitivity to penicillin.
Patients, themselves or whose parents or brothers are constitutionally predisposed to allergic symptoms such as bronchial asthma, rash, urticaria, etc.
Patients with severe renal disorder.
Patients who are in poor condition systemically, unable to take diet in parenteral, and the aged (as the deficiency symptoms of vitamin K occurs, monitor carefully).
General Precautions: For the prevention of manifestation of resistant bacteria, in principle, administer this drug ring minimum period after conforming the susceptibility.
Regular clinical monitoring (hepatic function, renal function, blood, etc.) during therapy is advised.
This drug may be used concurrently with aminoglycoside antibiotics or metronidazole.
Others: Mild to moderate hearing loss has been reported in a few pediatric patients receiving cefuroxime sodium for the treatment of meningitis. Persistence of positive CSF cultures at 18-36 hours has been observed with cefuroxime sodium injection; however, the clinical relevance of this finding is unknown.
Use in Pregnancy: As the safety during pregnancy has not yet been established, this drug should be used during pregnancy or suspected pregnancy only if the potential benefit justifies the potential risk.
Use in Lactation: It is reported that this drug is secreted in human milk. Thus, should be used with caution in lactating mothers.