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Premature Discontinuation of Apixaban Increases the Risk of Thrombotic Events: Premature discontinuation of any oral anticoagulant, including apixaban increases the risk of thrombotic events. To reduce this risk, consider coverage with another anticoagulant if apixaban is discontinued for a reason other than pathological bleeding or completion of a course of therapy.
Spinal/Epidural Hematoma: Epidural or spinal hematomas may occur in patients treated with apixaban who are receiving neuraxial anesthesia or undergoing spinal puncture. These hematomas may result in long-term or permanent paralysis. Consider these risks when scheduling patients for spinal procedures.
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