Xabitor 2.5/Xabitor 5 Dosage/Direction for Use

Prevention of VTE in elective hip or knee replacement surgery: 2.5 mg bid. Initial dose should be taken 12-24 hours after surgery. Recommended duration of treatment: 32-38 days for hip replacement surgery & 10-14 days for knee replacement surgery.
Prevention of stroke & systemic embolism in Patient with NVAF: 5 mg bid.
Patient with at least 2 of the following characteristics: ≥80 yr, ≤60 kg, or serum creatinine ≥1.5 mg/dL (133 mmol/L): 2.5 mg bid.
DVT & PE: 10 mg bid for 7 days, followed by 5 mg bid.
Prevention of recurrent DVT & PE: 2.5 mg bid after at least 6 month of treatment for DVT or PE.
Surgery & invasive procedures: Patient not previously treated with anticoagulants: At least 5 doses of 5 mg bid (2.5 mg bid in patient who qualify for dose reduction) should be given before cardioversion to ensure adequate anticoagulation. If cardioversion is required before 5 doses of Apixaban: 10 mg loading dose, followed by 5 mg bid. Reduce to 5 mg loading dose, followed by 2.5 mg bid if the patient meets the criteria for dose reduction. Loading dose should be given at least 2 hours before cardioversion.
Method of Administration: May be taken with or without food. For patient with swallowing difficulties, crush tab & suspend in water, 5% dextrose in water (D5W), apple juice or mixed with applesauce. Drink immediately. Solution stable for 4 hours. Alternatively, crush & suspend in 60 mL water or D5W & administer via nasogastric tube.