Vocinti Dosage/Direction for Use

Gastric ulcer, duodenal ulcer: Usually, for adults, a daily oral dose of 20 mg of Vonoprazan is administered once a day. For the treatment of gastric ulcer, the usual administration should be limited up to 8 weeks, and for duodenal ulcer, up to 6 weeks.
Reflux esophagitis: Usually, for adults, a daily oral dose of 20 mg of Vonoprazan is administered once a day. The usual administration should be limited up to 4 weeks. However, when the effect if insufficient, the drug may be administered up to 8 weeks. In addition, for the maintenance of healing of reflux esophagitis in patients who repeat recurrence and relapse of the condition, a daily oral dose of 10 mg is administered once a day, however, when the efficacy is inadequate, a daily oral dose of 20 mg may be administered once a day.
Prevention of recurrence of gastric ulcer or duodenal ulcer during low-dose aspirin administration: Usually, for adults, a daily oral dose of 10 mg of Vonoprazan is administered once a day.
Prevention of recurrence of gastric ulcer or duodenal ulcer during NSAIDs administration: Usually, for adults, a daily oral dose of 10 mg of Vonoprazan is administered once a day.
Adjunct to Helicobacter pylori eradication: Usually, for adults, the following 3 drugs are orally administered at the same time twice daily for 7 days: 20 mg/dose of Vonoprazan, 750 mg (potency)/dose as amoxicillin hydrate, and 200 mg (potency)/dose as clarithromycin. The dose of clarithromycin may be properly increased as the occasion demands, however, the upper limit is 400 mg (potency) twice daily.
When Helicobacter pylori eradication treatment with 3 drugs consist of a proton pump inhibitor, amoxicillin hydrate, and clarithromycin fails, alternative treatment with the following 3 drugs is given as follows; usually, for adults, 20 mg/dose of Vonoprazan, 750 mg (potency)/dose of amoxicillin hydrate, and 250 mg/dose of metronidazole are orally administered at the same time twice daily for 7 days.