Vildaxil Dosage/Direction for Use

Dosage: The management of antidiabetic therapy should be individualized.
The recommended dose of Vildagliptin is 50 mg once or twice daily. The maximum daily dose of Vildagliptin is 100 mg.
Adults: When used as monotherapy, in combination with metformin, in combination with thiazolidinedione, in combination with metformin and a sulphonylurea, or in combination with insulin (with or without metformin), the recommended daily dose of vildagliptin is 100 mg, administered as one dose of 50 mg in the morning and one dose of 50 mg in the evening.
When used in dual combination with a sulphonylurea, the recommended dose of vildagliptin is 50 mg once daily administered in the morning. In this patient population, vildagliptin 50 mg daily was no more effective than vildagliptin 50 mg once daily.
When used in combination with a sulphonylurea, a lower dose of the sulphonylurea may be considered to reduce the risk of hypoglycaemia.
Doses higher than 100 mg are not recommended.
If a dose of Vildagliptin [VILDAXIL] is missed, it should be taken as soon as the patient remembers. A double dose should not be taken on the same day.
The safety and efficacy of vildagliptin as triple oral therapy in combination with metformin and a thiazolidinedione have not been established.
Additional information on special populations: Elderly (≥65 years): No dose adjustments are necessary in elderly patients.
Renal impairment: No dose adjustment is required in patients with mild renal impairment (creatinine clearance ≥50 mL/min). In patients with moderate or severe renal impairment or with end-stage renal disease (ESRD), the recommended dose of Vildagliptin [VILDAXIL] is 50 mg once daily.
Hepatic impairment: Vildagliptin [VILDAXIL] should not be used in patients with hepatic impairment, including patients with pre-treatment alanine aminotransferase (ALT) or aspartate aminotransferase (AST) >3x the upper limit of normal (ULN).
Paediatric population: Vildagliptin [VILDAXIL] is not recommended for use in children and adolescents (<18 years). The safety and efficacy of Vildagliptin [VILDAXIL] in children and adolescents (<18 years) have not been established. No data are available.
Method of administration: Oral use.
Vildagliptin [VILDAXIL] can be administered with or without a meal.