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Antivertigo.
Cinnarizine is a selective calcium-entry blocker, belonging to group IV of calcium antagonists. It inhibits contractions of vascular smooth muscle cells by blocking calcium channels. In addition, it decreases the contractile activity of vasoactive substances eg, norepinephrine and serotonin, resulting to a remarkable improvement of cerebral blood flow.
Cinnarizine further improves deficient microcirculation by increasing erythrocyte deformity and decreasing blood viscosity. Cellular resistance to hypoxia is increased. Cinnarizine inhibits stimulation of the vestibular system, which results in suppression of nystagmus and other autonomic disturbances. Acute episodes of vertigo can be prevented or reduced.
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