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Pharmacology: Pharmacodynamics: Salbutamol is a selective Beta-2 adrenoceptor agonist. At therapeutic doses, it acts on the Beta-2 adrenoceptors of bronchial muscle, with little or no action on the Beta-1 adrenoceptors of cardiac muscle. Guaifenesin can make the viscous mucus of the respiratory pathway more fluid and therefore expectoration and reduces cough.
Pharmacokinetics: Salbutamol is absorbed from the gastrointestinal tract and undergoes considerable first-pass metabolism to the phenolic sulfate. Both unchanged drug and conjugate are excreted primarily in the urine. The bioavailability of orally administered salbutamol is about 50%.
Guaifenesin is well-absorbed after oral administration. After the administration of guaifenesin 600 mg in healthy adult volunteers, the maximum peak plasma concentration (Cmax) was approx 1.4 mcg/mL with Tmax about 15 minutes after drug administration.
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