Velbastine Overdosage

Adverse reactions following the use of vinblastine sulfate are dose-related. Therefore, following administration of more than the recommended dose, patients can be expected to experience these effects in an exaggerated fashion. There is no specific antidote.
Treatment: Prevention of adverse effects that result from the syndrome of inappropriate secretion of antidiuretic hormone (this would include restriction of the volume of daily fluid intake to that of the urine output plus insensible loss and perhaps the administration of a diuretic affecting the function of the loop of Henle and the distal tubule);
Administration of an anticonvulsant (Phenobarbital); Use of enemas or cathartics to prevent ileus (In some instances, decompression of the gastrointestinal tract may be necessary.);
Monitoring the cardiovascular system; Determining daily blood counts for guidance in transfusion requirements and assessing the risk of infection. If necessary, give a blood transfusion. Protect the patient's airway and support ventilation and perfusion. Meticulously monitor and maintain, within acceptable limits, the patient's vital signs, blood gases, serum electrolytes, etc.