Valparin XR 500 Adverse Reactions

Rare cases of liver dysfunction (see Precautions).
Confusion or convulsions: a few cases of stupor either isolated or associated with an upsurge in convulsions with sodium valproate have been observed, and they regress on discontinuation of treatment or dosage reduction. These states usually occur in the multiple-drug treatment context (especially Phenobarbital) or on abrupt increase of sodium valproate doses.
Certain subjects may present, at the beginning of treatment, gastrointestinal disturbances (nausea, gastric pain), which generally stop after a few days, without discontinuation of treatment.
Transient dose-dependent adverse effects have been reported; hair-loss, fine postural tremor.
Weight gain has been observed, as have amenorrhea and menstrual disturbances.
Dose related rise in bleeding time, decrease in fibrinogen have been reported.
Hematologic side effects: thrombocytopenia, rarely anemia, leucopenia or pancytopenia.
Isolated hyperammonaemia without change in liver function tests may occur. This should not cause treatment discontinuation.
Rarely pancreatitis, vasculitis, hearing loss.
Patient to seek medical attention immediately at the first sign if any adverse reaction shall appear.