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Pregnancy: There are no adequate and well-controlled studies of ivabradine in pregnant women. However, embryo-fetal toxicity and cardiac teratogenic effects were observed in fetuses of pregnant rats treated during organogenesis at exposures 1 to 3 times the human exposures (AUC0-24hr) at the maximum recommended human dose (MRHD). Therefore, ivabradine is contraindicated during pregnancy.
Lactation: It is not known if ivabradine is distributed in human milk. However, animal studies have shown that ivabradine is distributed into milk in rats. Therefore, ivabradine is contraindicated during breastfeeding.
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