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Vactazo

Vactazo Mechanism of Action

piperacillin + tazobactam

Manufacturer:

Inject Care Parenterals

Distributor:

D & G Pharma
Full Prescribing Info
Action
Pharmacology: Pharmacokinetics: Both Piperacillin and Tazobactam are not well absorbed in the GIT but have good bioavailability after an IM injection. They are both widely distributed into different body compartment but penetration into the meninges of Tazobactam is poor when meninges are not inflamed. Tazobactam is metabolized to a single inactive metabolite while Piperacillin is metabolized to the dethyl metabolite, which has minor activity. Approximately 68% and 80% of an administered dose of Piperacillin and Tazobactam, respectively are excreted unchanged in the urine.
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