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Powerful enzyme inducers such as barbiturates, antiepileptic agents (phenytoin), rifampicin, phenylbutazone, spironolactone and griseofulvin. These drugs enhance metabolisation in the liver.
Certain antibiotics (ampicillin, tetracyclines): variations in the intestinal flora, which lead to a change in the enterohepatic circulation of steroids.
Progestins may cause a reduction in glucose tolerance, which increases the need for insulin and other anti-diabetic agents in diabetic patients.
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