Urlyx/Urlyx 500 Dosage/Direction for Use

Urlyx: Initial dose of 1 capsule every 8 hours or as prescribed by the physician.
Urlyx 500: Recommended Dose: The recommended adult dosage for Ursodeoxycholic acid in the treatment of PBC is 13-15 mg/kg/day administered in two to four divided doses with food. The Ursodeoxycholic acid, 500 mg scored tablet can be broken in halves to provide recommended dosage.
Dosing Considerations: Patient Monitoring: Serum liver function tests (γ-GT, alkaline phosphatase, AST, ALT) and bilirubin level should be monitored every month for three months after start of therapy, and every six months thereafter. Serial monitoring will allow for the early detection of a possible deterioration of the hepatic function. Serum levels of these parameters usually decrease rapidly. Improved serum liver tests (e.g. AST, ALT) do not always correlate with improved disease status. For patients who have a recent history of adequate biochemical response to the treatment, UDCA discontinuation should be considered when serum liver function tests increase to a level considered clinically.
Caution has to be exercised to maintain the bile flow of the patients taking UDCA.