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Pharmacology: Pharmacokinetics: Tamsulosin is absorbed from the gastrointestinal tract and is almost completely bioavailable. The extent and rate of absorption are reduced in the presence of food. Following oral administration of an immediate release preparation, peak plasma concentrations occur about 1 hour after a dose. Tamsulosin is metabolized slowly in the liver and is excreted mainly in the urine as metabolites and some unchanged drug. The plasma elimination half-life has been reported to be between 4 and 5.5 hours. Tamsulosin is about 99% bound to plasma proteins.
Some of the pharmacokinetic value cited above may be altered when tamsulosin is administered as a modified-release preparation, the form in which it is usually employed; for instance, peak plasma concentrations occur about 6 hours after a dose and the apparent elimination half-life may be 10 to 15 hours.
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