Unitaxel Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Paclitaxel

Indications/Uses

Metastatic carcinoma of the ovary or breast, after failure of standard therapy.

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Dosage/Direction for Use

175 mg/m² IV over 3 hr every 3 wk. Premed prior to Unitaxel: Oral dexamethasone 20 mg 12 & 6 hr before Unitaxel, diphenhydramine 50 mg IV 30-60 min & cimetidine 300 mg prior to Unitaxel or ranitidine 50 mg IV 30-60 min before Unitaxel.

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Overdosage

View Unitaxel overdosage for action to be taken in the event of an overdose.

Contraindications

Hypersensitivity to paclitaxel or other drugs formulated in cremophor + EL (polyethoxylated castor oil); patients w/ severe baseline neutropenia (<1,500 cells/mm³). Pregnancy & lactation.

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Special Precautions

Monitor occurrence of myelotoxicity. Perform frequent peripheral blood cell count. Monitor vital signs during 1st hr of infusion. Monitor cardiac function in patients who develop serious conduction abnormalities.

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Use In Pregnancy & Lactation

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Adverse Reactions

Bone marrow suppression, neutropenia, thrombocytopenia, anemia; flushing, rash; hypotension, bradycardia; paresthesia, arthralgia, myalgia, alopecia; nausea, vomiting, diarrhea & mucositis, alopecia; bilirubin, alkaline, severe elevations in AST, alkaline phosphatase, or bilirubin.

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Drug Interactions

Cisplatin enhances myelosuppressive action.

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Storage

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Description

View Unitaxel description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Cytotoxic Chemotherapy

ATC Classification

L01CD01 - paclitaxel ; Belongs to the class of taxanes from plant alkaloids and other natural products. Used in the treatment of cancer.

Regulatory Classification

Presentation/Packing

Form

Unitaxel inj 150 mg/25 mL

Packing/Price

1's

Form

Unitaxel inj 300 mg/50 mL

Packing/Price

1's

Unitaxel

paclitaxel

Manufacturer:

Korea United Pharma

Distributor:

Qualimed