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Fertility: Animal reproduction studies have revealed no evidence of impaired fertility or harm to the fetus due to ampicillin and sulbactam.
Use During Pregnancy: Sulbactam and ampicillin cross the placental barrier. Safety for use during pregnancy has not been established. Therefore, ampicillin sodium/sulbactam sodium should be used during pregnancy only if the potential benefits outweigh the potential risks.
Use During Lactation: Low concentrations of sulbactam (~0.13 up to 2.8 mg/L) and ampicillin (~0.11 up to 3 mg/L) are excreted in the milk. The use of ampicillin sodium/sulbactam sodium by a nursing mother may lead to adverse effects such as diarrhea in the child. Ampicillin sodium/sulbactam sodium can be used during lactation if the potential benefits outweigh the potential risks.
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