Careful administration should be exercised in case that the patients with jaundice and hepatic cirrhosis. Regularly check the level of liver enzymes (ALT, AST, γ-GT, ALP, total bilirubin). There is a faint chance that an overdose causes a severe adverse event. If necessary, perform liver function test. There is no evidence that dose adjustment in geriatric patients is necessary. However, appropriate precautions should be exercised such as reducing the dose because the physical functions in elderly patients generally declines.