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Management of acute overdosage with Levodopa + Carbidopa (Twindopa) is basically the same as management of acute over dosage with levodopa; however, pyridoxine is not effective in reversing the actions of Levodopa + Carbidopa (Twindopa). ECG monitoring should be instituted, and the patient carefully observed for the possible development of arrhythmias; if required, appropriate anti-arrhythmic therapy should be given. The possibility that the patient may have taken other drugs as well as Levodopa + Carbidopa (Twindopa) should be taken into consideration. To date, no experience has been reported with dialysis, and hence its value in the treatment of over dosage is not known.
The terminal half-life of levodopa is about two hours in the presence of carbidopa.
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