Triolev-200/Triolev

Triolev-200 Treatment of susceptible infections including URTI (eg, bacterial pharyngitis, tonsillitis, otitis media, sinusitis), lower resp tract infections (eg, acute bronchitis), UTI (eg, acute uncomplicated cystitis & urethritis), uncomplicated gonorrhea. Triolev Treatment of susceptible infections including sequential treatment after initial IV chemotherapy w/ parenteral cephalosporin, resp tract infections, otitis media, UTI, gonorrhoea & typhoid fever.

Triolev-200 Adult Recommended dose: 400 mg once daily or 200 mg every 12 hr. Uncomplicated cervical/urethral gonococcal infections 400 mg as single dose. Childn Recommended dose: 8 mg/kg/day as single dose or 4 mg/kg every 12 hr. Typhoid 15-20 mg/kg/day as single dose or divided into 2 equal doses every 12 hr for 7-14 days. Infections due to S. pyogenes Administer at least 10 days. Triolev Childn Recommended dose: 8 mg/kg/day as single dose or 4 mg/kg every 12 hr. Typhoid 20 mg/kg/day in 2 divided doses or as single dose. Infections due to S. pyogenes Administer at least 10 days.

May be taken with or without food: May be taken w/ food or milk to reduce GI discomfort.

Hypersensitivity to cefixime or other cephalosporins. Triolev-200 Patients w/ renal impairment w/ CrCl <60 mL/min. Triolev Patients w/ previous, immediate &/or severe hypersensitivity to penicillin or any β-lactam antibiotics. Preterm & term newborn infants (0-27 days).

Patients w/ history of hypersensitivity to penicillin or other drugs. Discontinue treatment & take appropriate therapy &/or measure in case of severe cutaneous adverse reactions; severe hypersensitivity/anaphylactic reactions; acute renal failure. Risk of pseudomembranous colitis. Prolonged use may result in overgrowth of non-susceptible organisms. Should not be used during pregnancy & lactation unless considered essential. Triolev-200 Risk of encephalopathy (which may include convulsions, confusion, impairment of consciousness, movement disorders), particularly in overdose or renal impairment; drug-induced hemolytic anaemia; acute renal failure including tubulointerstitial nephritis. Patients w/ markedly impaired renal function. Safety in premature or newborn infants has not been established. Triolev Concomitant use w/ nifedipine. Patients w/ rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine. Adult patients w/ CrCl <20 mL/min. Not recommended in ped & adolescents w/ renal insufficiency.

Diarrhea & stool changes; headache & dizziness; allergies in the form of rash, pruritus urticaria, drug fever & arthralgia; thrombocytopenia, leukopenia & eosinophilia; genital pruritus & vaginitis.

Triolev-200 May enhance effects of coumarin-type anticoagulants. False +ve reaction for glucose in the urine using Benedict's or Fehling's soln or w/ Cu sulphate test tab. False +ve direct Coombs' test. Triolev Bioavailability may be increased w/ nifedipine. May increase prothrombin times in patients receiving anticoagulants.

Cephalosporins

J01DD08 - cefixime ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.

Rx