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Pharmacotherapeutic Group: Topical corticosteroid and anti-infective in combination.
Pharmacology: Pharmacodynamics: Mechanism of Action: Betamethasone/Clotrimazole/Gentamicin (TRIDERM) Ointment combines the sustained anti-inflammatory, antipruritic and vasoconstrictive actions of betamethasone dipropionate with the broad spectrum antifungal activity of clotrimazole and the wide-spectrum bactericidal antibiotic activity of gentamicin sulfate. Clotrimazole appears to act on the fungal cell membrane, causing leakage of cell contents. Gentamicin provides highly effective topical treatment in primary and secondary bacterial infections of the skin.
Pharmacodynamic Effects: Bacteria susceptible to gentamicin include sensitive strains of Staphylococcus aureus (coagulase positive, coagulase negative and some penicillinase-producing strains) and the gram-negative bacteria: Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Proteus vulgaris and Klebsiella pneumoniae.
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