Tricexone Dosage/Direction for Use

Adults and adolescents aged over 12 years with a body weight ≥50 kg: The usual dose is 1-2 g of Ceftriaxone, administered once a day. In cases of serious infections or infections caused by moderately sensitive micro-organisms the dose can be raised up to 4 g, administered once a day.
Newborn infants (age 0 - 14 days): 20-50 mg per kg bodyweight intravenously once daily. In severe infections the daily dose of 50 mg per kg bodyweight must not be exceeded.
Children 15 days to 2 years of age with a body weight of <50 kg: 20-80 mg per kg bodyweight intravenously once daily. In severe infections the daily dose of 80 mg per kg bodyweight must not be exceeded, except in meningitis.
Children with a bodyweight of 50 kg or more receive the usual adult dosage once daily.
Elderly: The normal adult dose can usually be given to elderly patients, unless renal and hepatic function is significantly impaired.
Dosage in special situations: Meningitis: In children with bacterial meningitis the therapy should be started with 100 mg/kg (not exceeding 4 g), administered once a day. After determining the sensitivity of the pathogen the dose may be reduced accordingly.
In new-born infants below 2 weeks of age the dose should not exceed 50 mg/kg/24 h.
Renal insufficiency: In patients with impaired renal function, alteration of the Ceftriaxone dose is not necessary, provided that the hepatic function is normal. Only in cases of extreme renal insufficiency (creatinine clearance <10 mL/min) the daily dose of the Ceftriaxone should not exceed 2 g.
In co-existing severe renal and hepatic insufficiency and in children with extreme renal insufficiency the serum Ceftriaxone concentrations should be regularly monitored, and the dosage adjusted appropriately. Patients undergoing haemodialysis or peritoneal dialysis do not need an additional dose of Ceftriaxone after the dialysis.
Serum concentrations should be monitored, however, to determine whether dosage adjustments are necessary, since the elimination rate in these patients may be reduced.
Hepatic insufficiency: The dose does not need to be altered in patients with a liver disease provided that the renal function is normal.
Direction For Reconstitution: Dissolve the contents of vial in 9.6 mL Sterile Water for Injection for IV injections or in 3.6 mL Sterile Water for Injection for IM injections.