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In case of large quantities of the vaginal suppository are used, systemic effects due to metronidazole may occur; however, no life-critical indications are expected due to metronidazole applied through vaginal route.
Symptomatic and supporting treatment is applied on overdose. There is no specific antidote to metronidazole. Symptoms due to metronidazole overdose are nausea, vomiting, abdominal pain, diarrhea, itching, metallic taste, ataxia, vertigo, paresthesia, convulsion, leukopenia, darkening of urine; symptoms due to miconazole nitrate overdosage are sore throat and mouth, anorexia, nausea, vomiting, headache, diarrhea. Lidocaine may cause cardiac rhythm disorders, shortness of breath, coma and even death, especially if applied to extensive skin surfaces and especially in very high doses.
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