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Hypersensitivity to the active substances or to any of the excipients of the medicinal product.
Acute intoxication with alcohol, hypnotic drugs, centrally-acting analgesics, opioids or psychotropic drugs.
Tramadol + Paracetamol should not be administered to patients who are receiving monoamine oxidase inhibitors or within two weeks of their withdrawal.
Severe hepatic impairment.
Epilepsy not controlled by treatment.
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