Serotonin syndrome has been reported in a patient taking ademetionine and clomipramine. Therefore, although a potential interaction is postulated, caution is recommended when administering ademetionine concomitantly with selective serotonin reuptake inhibitors (SSRI), tricyclic antidepressants (such as clomipramine), and over-the-counter and herbal supplements containing tryptophan. (See Precautions.)