Tracy Drug Interactions

Use with MAO inhibitors and SSRIs: Interaction with MAO inhibitors have been reported for some centrally-acting drugs. (See Precautions.)
Use with Carbamazepine: Concomitant administration of Tramadol HCl and carbamazepine causes a significant increase in Tramadol HCl metabolism. Patients taking carbamazepine may have a significantly reduced analgesic effect from the Tramadol HCl component of Tracy.
Use with Quinidine: Tramadol HCl is metabolized to M1 by CYP2D6. Concomitant administration of quinidine and Tramadol HCl results in increased concentrations of Tramadol HCl. The clinical consequences of these findings are unknown.
Use with Warfarin-Like Compounds: As medically appropriate, periodic evaluation of prothrombin time should be performed when Paracetamol + Tramadol HCl and these agents are administered concurrently due to reports of increased International Normalized Ratio (INR) in some patients.
Use with Inhibitors of CYP2D6: In vitro interaction studies in human liver microsomes indicate that concomitant administration with inhibitors of CYP2D6 (e.g., fluoxetine, paroxetine and amitriptyline) could result in some inhibition of the metabolism of Tramadol HCl.
Use with Cimetidine: Concomitant administration of Paracetamol + Tramadol HCl and cimetidine has not been studied. Concomitant administration of Tramadol HCl and cimetidine does not result in clinically significant changes in Tramadol HCl pharmacokinetics.