Tpiao Adverse Reactions

Adverse reactions have been observed rarely. Fever, myalgia and dizziness occurred occasionally and most of them could recover automatically. Clear symptoms which happened in individual patients can be corrected by expectant treatments. The severe reactions have not been observed in the 3 clinical trials. Among the 311 patients, the gentle adverse reaction associated with rhTPO occurred in 18 patients. Among them, the adverse reactions experienced were fever (4 patients), shiver (2 patients), discomfort from head to foot (1 patient), fatigue (2 patients), arthralgia (2 patients), headache (2 patients), dizziness (3 patients) and increased blood pressure (2 patients). But the symptoms were mostly gentle and need not the special disposal. The results of examination in the laboratory showed the rhTPO had no influence on the recovery of the amount of hemoglobin and leukocyte after chemotherapy; and have no notability influence in the shape and aggregation of blood platelet and the functions of coagulation, liver and renal. Seventy-four (74) patients received the detection of dynamic antibody in the treatment cycle. The low titer (1:5) non-neutralization antibody of rhTPO were detected in the serum of 3 patients at the 21 days and 28 days after administration. The influence on the function of rhTPO to increase the level of blood platelet has not been observed.