Topvex 25/Topvex 50/Topvex 100 Dosage/Direction for Use

For optimal seizure control, in both adults and children, it is recommended that therapy be initiated at a low dose, followed by titration to an effective dose. It is recommended that film-coated tablets not be broken.
Topiramate can be taken without meals.
Adults: Therapy should begin at 25-50 mg nightly for one week. Subsequently, the dose should be increased at weekly intervals by 25-50 mg/day and taken in two divided doses. Dose titration should be guided by clinical outcome. Some patients may achieve efficacy with once-a-day dosing. The effective dose is usually within the range of 200 mg (minimum dose) to 400 mg daily taken in two divided doses; some patients may require up to 800 mg (maximum dose) daily. It is recommended that therapy be initiated at a low dose, followed by titration to an effective dose.
Since Topiramate is removed from plasma by haemodialysis, an additional dosage equal to approximately one-half of the daily dose should be administered on haemodialysis days. The additional dose should be administered in divided doses at the beginning and completion of the haemodialysis procedure. The additional doses may vary based on the dialysis equipment being used. No dosage adjustment is necessary in elderly patients.
Children 4 years and over: The initial dose for children is 25 mg for the first week, increased at intervals of 1–2 weeks by increments of 1 to 3 mg/kg/day, administered in two divided doses if more than 25 mg per day. The recommended dose thereafter is about 5–9 mg/kg/day in two divided doses. Dose titration should be guided by clinical outcome.