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Topotecan monotherapy is indicated for the treatment of: Patients with metastatic carcinoma of the ovary after failure of first-line or subsequent therapy.
Patients with relapsed small cell lung cancer [SCLC] for whom re-treatment with the first-line regimen is not considered appropriate (see Pharmacology: Pharmacodynamics under Actions).
Topotecan in combination with cisplatin is indicated for patients with carcinoma of the cervix recurrent after radiotherapy and for patients with Stage IVB disease. Patients with prior exposure to cisplatin require a sustained treatment free interval to justify treatment with the combination (see Pharmacology: Pharmacodynamics under Actions).
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