Topoblock Dosage/Direction for Use

Combination Therapy: Irinotecan can be administered in two different regimens in combination with 5-flourouracil and leucovorin for the treatment of colorectal cancer. Irinotecan 125 mg/m² is administered as I.V on 90 min on days 1, 8, 15 & 22 followed by leucovorin 20 mg/m² as I.V bolus on same days. 5-flourouracil should be administered immediately after administration of leucovorin at a dose of 500 mg/m². Thereafter the additional courses are repeated after every 6 weeks (4 weeks on therapy, 2 weeks off therapy). After initiation of chemotherapy the patient should be carefully monitored for toxicity and doses of irinotecan, LV and 5-FU should be modified as necessary to accommodate individual patient's tolerance to treatment. (See Table 1.)

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Irinotecan 180 mg/m² is administered as IV over 90 minutes on days 1, 15, 29 followed by LV 200 mg/m² over 2 hours on days 1, 2, 15, 16, 29 & 30.
5-FU should be administered immediately after administration of LV at a dose of 400 mg/m² I.V bolus. The bolus of 5-FU should be followed by infusional 5-FU at a dose of 600 mg/m² over 22 hours on days 1, 2, 15, 16, 29 and 30. Next course begins on day 43. After initiation of chemotherapy the patient should be carefully monitored for toxicity and doses of irinotecan, LV and 5-FU should be modified as necessary to accommodate individual patient's tolerance to treatment. (See Table 2.)

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