Tomexia Drug Interactions

Increased bleeding time has been seen when TOMEXIA is given in conjunction with acetylsalicylic acid and warfarin, but without hemorrhagic complications (see Precautions).
Acetylsalicylic acid: Patients should be informed about potential increased bleeding time.
Warfarin and coumarin: The prothrombin time/international normalized ratio (PT/INR) must be monitored during combination treatment with TOMEXIA among patients receiving blood-thinning therapy, and when treatment with TOMEXIA is discontinued.
Statins: TOMEXIA has been administered with simvastatin 80 mg under fasting conditions to 24 healthy volunteers in a two 14-days period drug-drug interaction study. Results of this study demonstrated that at steady state, the co-administration of TOMEXIA capsules with simvastatin did not appear to affect the pharmacokinetics of simvastatin tablets.
The combination appeared to be well tolerated. TOMEXIA has been given in conjunction with warfarin without hemorrhagic complications. However, the prothrombin time must be checked when TOMEXIA is combined with warfarin or when treatment with TOMEXIA is stopped.