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Due to its lipid emulsion content, the administration of TNA-Peri may rarely lead to acute reactions such as hyperthermia, sweating, shivering, headache, dyspnoea. If so, the infusion must be discontinued. During long term parenteral nutrition (6 to 8 weeks or more), temporary increase of alkaline phosphatase, transaminase and bilirubin levels has been reported. These parameters usually return to normal once the dosage has been reduced. Some cases of hepatomegaly and icterus have been very rarely noted. In some rare cases thrombopenia has been reported in children. Thrombophlebitis may occur during peripheral nutrition.
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