TIMOLOL MALEATE (TIMOPTOL) is contraindicated in patients with: Reactive airway disease, bronchial asthma or with a history of bronchial asthma, or severe chronic obstructive pulmonary disease, sinus bradycardia; sino-atrial block; second and third degree atrioventricular block; overt cardiac failure; cardiogenic shock, hypersensitivity to any component of this product