Thromboreductin Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Anagrelide HCl

Indications/Uses

Essential thrombocythemia.

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Dosage/Direction for Use

Individualized dosage. Initially 0.5 mg/day for 1 wk & increased wkly by 0.5 mg/day until desired therapeutic effect is achieved. Administer total daily dose bid (every 12 hr) or tid (every 8 hr). Max: 5 mg daily.

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Overdosage

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Administration

May be taken with or without food.

Contraindications

Hypersensitivity. Lactose intolerance; grade 4 or 3 CV diseases, severe renal (CrCl <30 mL/min) or liver (AST or ALT >5 times normal) disease. Pregnancy & lactation.

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Special Precautions

Patients w/ CV, renal or liver diseases. Hypotension & dizziness w/ high single dose (5 mg) & small & reversible BP decrease following single doses of 2 mg. Control hematological (eg, hematocrit & leukocyte count), renal & liver parameters in regular intervals during treatment. Childn <16 yr. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Headache, palpitations, diarrhea, weakness, edema, nausea, abdominal pain, dizziness, pain, dyspnea, flatulence, vomiting, fever, rash, chest pain, anorexia, tachycardia, pharyngitis, malaise, cough, paresthesia, back pain, pruritus, dyspepsia. Flu & flu-like symptoms, dehydration. Heart failure, MI, cardiomyopathy, heart block, atrial fibrillation, cerebrovascular events, pericarditis; pulmonary infiltrates, fibrosis & HTN; pancreatitis, GI ulcers, seizures.

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Drug Interactions

Increased heparin efficacy.

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Storage

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Description

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Action

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MIMS Class

Anticoagulants, Antiplatelets & Fibrinolytics (Thrombolytics)

ATC Classification

L01XX35 - anagrelide ; Belongs to the class of other antineoplastic agents. Used in the treatment of cancer.

Regulatory Classification

Presentation/Packing

Form

Thromboreductin cap 500 mcg

Packing/Price

100's

Thromboreductin

anagrelide

Manufacturer:

AOP Orphan

Distributor:

Globo Asiatico