Tazolitt Dosage/Direction for Use

For serious complicated infections: adults may be given 200 to 300 mg/kg daily in divided doses intravenously: the usual dose is 3 to 4 g every 4 to 6 hours.
For mild or uncomplicated infections: 100 to 125 mg/kg daily may be given to adults; usual doses are 2 g every 6 to 8 hours, or 4 g every 12 hours, intravenously, or 2 g every 8 or 12 hour intramuscularly.
Uncomplicated gonorrhoea: single intramuscular dose of 2 g.
For prophylaxis infection during surgery: 2 g just before the procedure.
Or as prescribed by the physician.
Piperacillin/Tazobactam should be administered by intravenous infusion over 30 minutes.
Adult Patients: The usual total dose of piperacillin/tazobactam for adults is 3.375 g every six hours totaling 13.5 g (12.0 g piperacillin/1.5 g tazobactam). The usual duration of piperacillin/tazobactam treatment is from 7 to 10 days. Piperacillin/Tazobactam should be administered by intravenous infusion over 30 minutes.
Nosocomial Pneumonia: Initial presumptive treatment of patients with nosocomial pneumonia should start with piperacillin/tazobactam at a dosage of 4.5 g every six hours plus an aminoglycoside, totaling 18.0 g (16.0 g piperacillin/2.0 g tazobactam). The recommended duration of piperacillin/tazobactam treatment for nosocomial pneumonia is 7 to 14 days. Treatment with the aminoglycoside should be continued in patients from whom P. aeruginosa is isolated.
Renal Impairment: In patients with renal impairment (creatinine clearance ≤40 mL/min) and dialysis patients (hemodialysis and CAPD), the intravenous dose of piperacillin/tazobactam should be reduced to the degree of actual renal function impairment. The recommended daily of doses of piperacillin/tazobactam for patients with renal impairment are as follows: (see Table 1).

Click on icon to see table/diagram/image

For patients on hemodialysis, the maximum dose is 2.25 g every twelve hours for all indications other than nosocomial pneumonia and 2.25 g every eight hours for nosocomial pneumonia. Since hemodialysis removes 30% to 40% of the administered dose, an additional dose of 0.75 g piperacillin/tazobactam (0.67 g piperacillin/0.08 g tazobactam) should be administered following each dialysis period on hemodialysis days. No additional dosage of piperacillin/tazobactam is necessary for CAPD patients.
Pediatric Patients: For children with appendicitis and/or peritonitis 9 months of age or older, weight up to 40 kg, and normal renal function, the recommended piperacillin/tazobactam dosage is 100 mg piperacillin/12.5 mg tazobactam per kilogram of body weight, every 8 hours.
For pediatric patients between 2 months and 9 months of age, the recommended piperacillin/tazobactam dosage based on pharmacokinetic modeling, is 80 mg piperacillin/10 mg tazobactam per kilogram of body weight, every 8 hours. Pediatric patients weighing over 40 kg with normal renal function.
It has not been determined how to adjust piperacillin/tazobactam dosage in pediatric patients with renal impairment.
Direction for Reconstitution: 4 g/500 mg should be reconstituted with 20 mL. Swirl until dissolved.
It should be used immediately after reconstitution. Discard any unused portion after 24 hours if stored at room temperature (20°C to 25°C) or after 48 hours if stored at refrigerated temperature (2°C to 8°C). Compatible Reconstitution Diluents: Sterile Water for Injection.