Tapimycin Dosage/Direction for Use

Piperacillin and Tazobactam for injection should be administered by intravenous infusion over 30 minutes.
The usual total daily dose of Piperacillin and Tazobactam for injection for adults is 3.375 g every 6 hours totaling 13.5 g (12.0 g Piperacillin/1.5 g Tazobactam).
For children with appendicitis and/or peritonitis 9 months of age or older, weighing up to 40 kg, and with normal renal function, the recommended Piperacillin and Tazobactam for injection dosage is 100 mg Piperacillin/12.5 mg Tazobactam per kilogram of body weight, every 8 hours.
For pediatric patients between 2 months and 9 months of age, the recommended Piperacillin and Tazobactam for injection dosage based on pharmacokinetic modeling, is 80 mg Piperacillin/10 mg Tazobactam per kilogram of body weight, every 8 hours.
Pediatric patients weighing over 40 kg and with normal renal function should receive the adult dose. There are no dosage recommendations for Piperacillin and Tazobactam for injection in pediatric patients with impaired renal function.
Impaired renal function: In patients with renal insufficiency the intravenous dose should be adjusted to the degree of actual renal function impairment. The suggested daily doses are: See table.

Click on icon to see table/diagram/image

For patients on haemodialysis, the maximum dose is 2.25 g every 12 hours for all indications. Since hemodialysis removes 30% to 40% of the administered dose, an additional dose of 0.75 g Piperacillin and Tazobactam for injection should be administered following each dialysis period on hemodialysis days. No additional dosage of Piperacillin and Tazobactam for injection is necessary for CAPD patients.
The reconstituted solution may be further diluted to 50 mL with water for injection, 5% dextrose injection, 0.9% sodium chloride injection.
The diluted solutions should be used immediately.
To be dispensed on Physician's prescription.