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The pharmacokinetic interaction between cimetidine and tamsulosin HCl was investigated. The results indicate significant changes in tamsulosin HCl clearance (26% decrease) and AUC (44% increase). Therefore tamsulosin HCl capsules should be used with caution in combination with cimetidine, particularly at doses >400 mcg.
Caution should be exercised with concomitant administration of warfarin and tamsulosin HCl.
Tamsulosin HCl should be used with caution in combination with moderate or strong inhibitors of CYP2D6 (eg, fluoxetine) or CYP3A4 (eg, ketoconazole), particularly at doses >400 mcg.
Tamsulosin and calcium channel blocker may increase the risk of hypotension. Risk of 1st-dose orthostatic hypotension may increase with β-blocker.
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