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No specific antidote is known. There is no known way of rapidly removing flecainide from the system, but forced acid diuresis may theoretically be helpful.
Neither dialysis nor haemoperfusion is helpful and injections of anticholinergics are not recommended.
Treatment may include therapy with an inotropic agent, intravenous calcium, giving circulatory assistance (e.g. balloon pumping), mechanically assisting respiration, or temporarily inserting a transvenous pacemaker if there are severe disturbances or the patient's left ventricular function is otherwise compromised.
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