Synalar 10/Synalar 25/Synalar HP Mechanism of Action

Synalar 10/Synalar 25: Fluocinolone acetonide (Synalar 10/Synalar 25) is primarily effective because of the anti-inflammatory, antipruritic and vasoconstrictor actions of Fluocinolone acetonide.
Synalar HP: Pharmacology: Pharmacodynamics: Fluocinolone acetonide is primarily effective as anti-inflammatory, antipruritic and vasoconstrictor. It is a glucocorticoid receptor agonist that binds to cytoplasmic glucocorticoid receptor and subsequently translocates to the nucleus where it initiates the transcription of glucocorticoid responsive genes such as lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandin and leukotrienes. Both are potent mediators of inflammation. It exerts its vasoconstrictive effect through inhibition of nitric oxide synthase thereby blocking nitric oxide production and effectively diminishing the effect of nitric oxide on vascular smooth muscles leading to reduced blood flow.
Pharmacokinetics: Fluocinolone acetonide is well absorbed from the sites of application. When applied to broken skin, sufficient amount may be absorbed that produces systemic effects. Mainly metabolized in the liver, but also in the kidney and is excreted in the urine.