Respect usual precautions and contraindications for any intra-articular injection. Do not inject intra-vascularly. SUPLASYN should not be used in patients presenting an inflammation/irritation of the joint, since adverse events more commonly occur in patients with already existing joint inflammation/irritation. As no clinical evidence is available on the use of Hyaluronic Acid in children, pregnant and lactating women, treatment with SUPLASYN is not recommended in these patients. The patient should rest 24-48 hours after the injection and avoid any strenuous activity over the full course of the treatment.