Use in Pregnancy: Pregnancy Category B. Diphenhydramine crosses the placental barrier and has been reported to cause jaundice and extrapyramidal symptoms in infants whose mothers received the drug during pregnancy. Drug therapy should be discontinued one to two weeks before the delivery to avoid these effects in the neonate. Therefore, diphenhydramine should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus.
Use in Lactation: Diphenhydramine is excreted in human milk. Therefore, use of diphenhydramine when breastfeeding is not recommended.
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