Solu-Cortef Description

Solu-Cortef (hydrocortisone sodium succinate or pregn-4-ene-3, 20-dione, 21-(3-carboxy-1-oxopropoxy)-11, 17-dihydroxy); monosodium salt, (11β) is an anti-inflammatory adrenocortical steroid. This highly water soluble sodium succinate ester of hydrocortisone permits the immediate intravenous administration of high doses of hydrocortisone in a small volume of diluent and is particularly useful where high blood levels of hydrocortisone are required rapidly.
When necessary, the pH of hydrocortisone sodium succinate (Solu-Cortef) was adjusted with sodium hydroxide so that the pH of the reconstituted solution is within the USP specified range of 7 to 8.
Solu-Cortef 100 mg: Hydrocortisone sodium succinate (Solu-Cortef) 100 mg Sterile Powder for Injection (IM/IV) contains hydrocortisone sodium succinate equivalent to 100 mg hydrocortisone, 1 mg monobasic sodium phosphate, 9 mg dibasic sodium, and 10% sodium hydroxide.
Solu-Cortef 100 mg/2 mL: Hydrocortisone sodium succinate (Solu-Cortef) 100 mg/2 mL Sterile Powder for Injection (IM/IV) contains hydrocortisone sodium succinate equivalent to 100 mg hydrocortisone/2 mL, 1 mg monobasic sodium phosphate, 10 mg dibasic sodium, and 10% sodium hydroxide.
Solu-Cortef 250 mg/2 mL: Hydrocortisone sodium succinate (Solu-Cortef) 250 mg/2 mL Sterile Powder for Injection (IM/IV) contains hydrocortisone sodium succinate equivalent to 250 mg hydrocortisone/2 mL, 2 mg monobasic sodium phosphate, 25 mg dibasic sodium phosphate, and 10% sodium hydroxide.
Solu-Cortef 500 mg/4 mL: Hydrocortisone sodium succinate (Solu-Cortef) 500 mg/4 mL Sterile Powder for Injection (IM/IV) contains hydrocortisone sodium succinate equivalent to 500 mg hydrocortisone/4 mL, 5 mg monobasic sodium phosphate, 52 mg dibasic sodium phosphate, and 10% sodium hydroxide.