Seremax Forte Drug Interactions

Since pregabalin is predominantly excreted unchanged in the urine, undergoes in the urine, undergoes negligible metabolism in human (<2% of a dose recovered in urine as metabolites), does not inhibit drug metabolite in vitro, and is not bound to plasma proteins, it is unlikely to produce, or be subject to pharmacokinetic interactions. Accordingly, in in vivo studies, no clinically relevant pharmacokinetic interactions were observed between pregabalin and phenytoin, carbamazepine, valproic acid, lamotrigine, gabapentin, lorazepam, oxycodone or ethanol. Population pharmacokinetic analysis indicated that oral antidiabetics, diuretics, insulin, Phenobarbital, tiagabine and topiramate has no clinically significant effect on pregabalin clearance. Co-administration of pregabalin with the oral contraceptives norethisterone and/or ethinyl oestradiol does not influence the steady-state pharmacokinetics of either substance.
Pregabalin may potentiate the effects of ethanol and lorazepam. In controlled clinical trials, multiple oral doses of pregabalin co-administered with oxycodone, lorazepam or ethanol did not result in clinically important effects on respiration. Pregabalin appears to be additive in the impairment of cognitive and gross motor function caused by oxycodone.
In the post marketing experience, there are reports of respiratory failure and coma in patients taking pregabalin and other central nervous system depressant medications. There are post-marketing reports of events related to reduce lower gastrointestinal tract function (eg, intestinal obstruction, paralytic ileus, constipation) when pregabalin was co-administered with medications that have the potential to produce constipation eg. Opioid analgesic. No specific pharmacodynamic interaction studies were conducted in elderly volunteers. Interaction studies have only been performed in adults.
Mecobalamin: There is no known adverse reactions when taken in conjunction with medication.
Alpha Lipoic Acid: Supplemental alpha lipoic acid any lower blood glucose levels.