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Prior to initiation of cefepime with tazobactam therapy, careful inquiry should be made concerning previous hypersensitivity reactions to cephalosporins, penicillins or other drugs.
If a hypersensitivity reaction occurs during cefepime with tazobactam therapy, the drug should be discontinued. Serious acute hypersensitivity reactions may require treatment with Epinephrine and other emergency measures including oxygen, corticosteroids, intravenous fluids, intravenous antihistamines, pressor amines, and airway management, as clinically indicated.
In patients with creatinine clearance less than or equal to 60 mL/min, the dose of cefepime hydrochloride should be adjusted to compensate for the slower rate of renal elimination.
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