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IV: Admixture Incompatibility: Amiodarone IV in D5W, in a concentration of 4 mg/mL, is incompatible and forms a precipitate with the following drugs: Aminophylline, cefamandole, cefazolin, mezlocillin. A concentration of 3 mg /mL Amiodarone IV in D5W forms a precipitate with sodium bicarbonate. Amiodarone is likewise incompatible with heparin.
Stability: Amiodarone adsorbs to polyvinyl chloride (PVC) tubing, and the clinical trial dose administration schedule was designed to account for this adsorption. Clinical trials were conducted using PVC tubing; therefore, its use is recommended.
Amiodarone has been found to leach out plasticizers, including di-ethylhexyl phthalate (DEHP) from IV tubing (including PVC tubing). The degree of leaching increases when infusing amiodarone IV at higher concentrations and lower flow rates than recommended.
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