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Use in Pregnancy: Category D: Doxorubicin can cause fetal harm when administered to a pregnant woman. Doxorubicin is embryotoxic and teratogenic in rats and embryotoxic and abortifacient in rabbits, and trace amounts of drug have been found in mouse fetuses and in one aborted human fetus following doxorubicin administration.
If doxorubicin is used during pregnancy, or if the patient becomes pregnant while receiving the drug, evaluate potential hazard to the fetus or potential risk of loss of pregnancy. Advise women of childbearing potential to avoid becoming pregnant during doxorubicin therapy.
Use in Lactation: Doxorubicin and doxorubicinol is distributed into breast milk. Mothers should not breastfeed while undergoing chemotherapy.
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