Rosuvastatin is given by mouth in an initial dose of 5 mg to 10 mg in the evening; an initial dose of 20 mg may be used in patients with ischaemic heart disease. The dose may be adjusted at interval of not less than 4 weeks up to maximum of 80 mg once daily in three divided doses of 20 mg, 20 mg, and an evening dose of 40 mg. A maximum of 10 mg daily is recommended in those taking ciclosporin, fibric acid derivatives, or nicotinic acid, and the risk of myopathy must be considered.